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Differential Scanning Calorimetry (DSC)

Differential Scanning Calorimetry (DSC) is unsurpassed for understanding the stability of biological systems.  DSC directly measures heat changes that occur in biomolecules during controlled increase or decrease in temperature, making it possible to study materials in their native state.

DSC measures the enthalpy (∆H) of unfolding due to heat denaturation. A biomolecule in solution is in equilibrium between the native (folded) conformation and its denatured (unfolded) state. The higher the thermal transition midpoint (T_m), when 50% of the biomolecules are unfolded, the more stable the molecule. DSC is also used to determine the change in heat capacity (ΔC_p) of denaturation.

What is DSC?

Products

MicroCal offers a range of Differential Scanning Calorimeters designed to meet the needs of life scientists, ranging from the industry standard VP-DSC to the advanced automated VP-Capillary DSC.

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